daf-16;tax-6

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Genetic mutants with daf-16, tax-6 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Diet
OP50
Lifespan (days)
14.33
Lifespan change (compared to wild type)
-17.31%
Phenotype
daf-16(mu86) suppressed the long life span of tax-6(p675) mutant animals.
Lifespan comparisons
Double mutant daf-16(mu86);tax-6(p675) has a lifespan of 14.33 days, while single mutant daf-16(mu86) has a lifespan of 13.33 days, single mutant tax-6(p675) has a lifespan of 20.0 days and wild type has a lifespan of 17.33 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Dong MQ et al., 2007, Quantitative mass spectrometry identifies insulin signaling targets in C. elegans. Science. 317(5838):660-3 17673661 Click here to select all mutants from this PubMed ID in the graph
Abstract
DAF-2, an insulin receptor-like protein, regulates metabolism, development, and aging in Caenorhabditis elegans. In a quantitative proteomic study, we identified 86 proteins that were more or less abundant in long-lived daf-2 mutant worms than in wild-type worms. Genetic studies on a subset of these proteins indicated that they act in one or more processes regulated by DAF-2, including entry into the dauer developmental stage and aging. In particular, we discovered a compensatory mechanism activated in response to reduced DAF-2 signaling, which involves the protein phosphatase calcineurin.

Temperature °C
20
Diet
OP50
Lifespan (days)
20.0
Lifespan change (compared to wild type)
19.05%
Phenotype
daf-16(mu86) suppressed the long life span of tax-6(p675) mutant animals.
Lifespan comparisons
Double mutant daf-16(mu86);tax-6(p675) has a lifespan of 20.0 days, while single mutant daf-16(mu86) has a lifespan of 13.2 days, single mutant tax-6(p675) has a lifespan of 14.9 days and wild type has a lifespan of 16.8 days.
Type of interaction
See methods
Antagonistic (positive)
Citation
View abstract
Dong MQ et al., 2007, Quantitative mass spectrometry identifies insulin signaling targets in C. elegans. Science. 317(5838):660-3 17673661 Click here to select all mutants from this PubMed ID in the graph
Abstract
DAF-2, an insulin receptor-like protein, regulates metabolism, development, and aging in Caenorhabditis elegans. In a quantitative proteomic study, we identified 86 proteins that were more or less abundant in long-lived daf-2 mutant worms than in wild-type worms. Genetic studies on a subset of these proteins indicated that they act in one or more processes regulated by DAF-2, including entry into the dauer developmental stage and aging. In particular, we discovered a compensatory mechanism activated in response to reduced DAF-2 signaling, which involves the protein phosphatase calcineurin.

Search genes: daf-16 tax-6

Entrez ID
Symbol
GenAge
Wormbase ID

172981
daf-16
View on GenAge (daf-16)
WBGene00000912

Forkhead box protein O;hypothetical protein

Locus: CELE_R13H8.1

Wormbase description: daf-16 encodes the sole C. elegans forkhead box O (FOXO) homologue; DAF-16 functions as a transcription factor that acts in the insulin/IGF-1-mediated signaling (IIS) pathway that regulates dauer formation, longevity, fat metabolism, stress response, and innate immunity; DAF-16 regulates these various processes through isoform-specific expression, isoform-specific regulation by different AKT kinases, and differential regulation of target genes; DAF-16 can interact with the CBP-1 transcription cofactor in vitro, and interacts genetically with other genes in the insulin signaling and with daf-12, which encodes a nuclear hormone receptor; DAF-16 is activated in response to DNA damage during development and co-regulated by EGL-27, alleviates DNA-damage-induced developmental arrest by inducing DAF-16-associated element (DAE)-regulated genes; DAF-16 is broadly expressed but displays isoform-specific tissue enrichment; DAF-16 localizes to both the cytoplasm and the nucleus, with the ratio between the two an important regulator of function.

Entrez ID
Symbol
GenAge
Wormbase ID

177943
tax-6
View on GenAge (tax-6)
WBGene00006527

Serine/threonine-protein phosphatase 2B catalytic subunit

Locus: CELE_C02F4.2

Wormbase description: tax-6 encodes an ortholog of calcineurin A that is required for inhibition and adaptation of several sensory neurons and for the normal regulation of egg-laying by serotonin; TAX-6 stimulates transcription of rcn-1, and binds RCN-1 protein if free Ca[2+] is present; in general, calcineurin positively regulates calcium-dependent signaling; tax-6 loss-of-function mutants exhibit an extended lifespan which is characterized by enhanced autophagy and dependent upon the presence of functional bec-1.

Orthologs of daf-16;tax-6 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Mus musculus	Foxo6;Ppp3cb
Mus musculus	Foxo6;Ppp3cc
Mus musculus	Foxo6;Ppp3ca
Mus musculus	Foxo1;Ppp3cb
Mus musculus	Foxo1;Ppp3cc
Mus musculus	Foxo1;Ppp3ca
Mus musculus	Foxo4;Ppp3cb
Mus musculus	Foxo4;Ppp3cc
Mus musculus	Foxo4;Ppp3ca
Mus musculus	Foxo3;Ppp3cb
Mus musculus	Foxo3;Ppp3cc
Mus musculus	Foxo3;Ppp3ca

Orthologs of daf-16 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Mus musculus	Foxo6
Mus musculus	Foxo1
Mus musculus	Foxo4
Mus musculus	Foxo3

Orthologs of tax-6 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	CanA1
Drosophila melanogaster	Pp2B-14D
Drosophila melanogaster	CanA-14F
Mus musculus	Ppp3cb
Mus musculus	Ppp3cc
Mus musculus	Ppp3ca