SynergyAge database

Long- and short-lived genetic mutants

Feel free to browse through the mutants recorded in our database

Caenorhabditis elegans Caenorhabditis elegans

1727 gene combinations 6635 lifespan values

Drosophila melanogaster Drosophila melanogaster

27 gene combinations 185 lifespan values

Mus musculus Mus musculus

36 gene combinations 147 lifespan values

Are the effects of lifespan determinants additive?

“A database of long- and short-lived mutants determined by synergistic or antagonistic genetic interventions”

1790 mutants with at least 2 genetic interventions

589 unique genes in 3 model organisms

6967 lifespan values

Variuos types of interventions (mutations, RNA interference, overexpression)

Data from peer-reviewed scientific literature

High quality manual curation

Easy to use interface

Visualization in a network form

Download available for your own analyses

SynergyAge effects

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020).

Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

Group webpage: