nuo-2;sad-1

Lifespan changes: From wild type to nuo-2;sad-1

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Genetic mutants with nuo-2, sad-1 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Diet

    NGM

  • Lifespan (days)

    18.4

  • Lifespan change (compared to wild type)

    6.98%

  • Phenotype

    The kinase involved in energy metabolism that we tested (sad-1) affected longevity induced by RNAi-mediated Mit mutants analyzed other than nuo-2 RNAi.

  • Lifespan comparisons

    Double mutant nuo-2(RNAi);sad-1(ky289) has a lifespan of 18.4 days, while single mutant nuo-2(RNAi) has a lifespan of 28.8 days, single mutant sad-1(ky289) has a lifespan of 18.6 days and wild type has a lifespan of 17.2 days.

  • Type of interaction
    See methods

    Antagonistic (positive)

  • Citation
    View abstract

    Schiavi A et al., 2013, Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans. Exp Gerontol. 48(2):191-201 PubMed 23247094 Click here to select all mutants from this PubMed ID in the graph

Search genes: nuo-2 sad-1
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

NADH Ubiquinone Oxidoreductase


Locus: CELE_T10E9.7


Wormbase description: nuo-2 encodes the C. elegans ortholog of the NDUFS3 subunit of mitochondrial complex I.


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Serine/threonine kinase SAD-1


Locus: CELE_F15A2.6


Wormbase description: sad-1 encodes a novel serine/threonine protein kinase; SAD-1 activity is required for several aspects of presynaptic development, including termination of axon outgrowth and presynaptic vesicle clustering, in GABAergic motor neurons and the ASI amphid chemosensory neuron; in addition, SAD-1 functions in a complex with STRD-1, with which it physically interacts in vivo, to regulate axonal-dendritic polarity and synapse organization; SAD-1 is expressed in the nervous system, where it localizes asymmetrically to the synapse-rich regions of axons; SAD-1 localization to synapses depends upon STRD-1; SAD-1 exhibits kinase activity in vitro, phosphorylating recombinant human Tau.


Orthologs of nuo-2;sad-1 in SynergyAge
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Orthologs of nuo-2 in SynergyAge
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Species Gene
Orthologs of sad-1 in SynergyAge
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Species Gene
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Contact
Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania
Email:

Group webpage: www.aging-research.group