oga-1;pdk-1

Lifespan changes: From wild type to oga-1;pdk-1

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Genetic mutants with oga-1, pdk-1 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Diet

    NGM; OP50

  • Lifespan (days)

    18.7

  • Lifespan change (compared to wild type)

    17.61%

  • Phenotype

    The combination of pdk-1(mg142) gain-of-function mutant alleles with the long-lived oga-1(ok1207) allele failed to suppress the lifespan extension associated with the oga-1 mutant. pdk-1(mg142) gain-of-function mutant lifespans are shorter than that of wild type.

  • Lifespan comparisons

    Double mutant oga-1(ok1207);pdk-1(mg142) has a lifespan of 18.7 days, while single mutant pdk-1(mg142) has a lifespan of 14.8 days, single mutant oga-1(ok1207) has a lifespan of 20.9 days and wild type has a lifespan of 15.9 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Rahman MM et al., 2010, Intracellular protein glycosylation modulates insulin mediated lifespan in C.elegans. Aging (Albany NY). 2(10):678-90 PubMed 20952811 Click here to select all mutants from this PubMed ID in the graph

Search genes: oga-1 pdk-1
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

O-GlcNAc selective N-Acetyl-beta-D-glucosaminidase (O-GlcNAcase)


Locus: CELE_T20B5.3


Wormbase description: oga-1 encodes an ortholog of mammalian O-linked N-acetylglucosamine (O-GlcNAc)-selective N-acetyl-beta-D-glucosaminidase (O-GlcNAcase); a polymorphism of OGA-1's human ortholog MGEA5 is associated with type 2 diabetes, and OGA-1 appears to be required for fine-tuning of insulin signalling; oga-1(ok1207) mutants are viable and fertile but accumulate O-GlcNAc on nuclear pores and other proteins, while showing S/T-phosphorylation of proteins, increased GSK-3beta activity, excess glycogen and trehalose, and decreased lipid storage; oga-1(ok1207) mutations enhance the Daf-c phenotype of daf-2(e1370ts) alleles even under conditions where oga-1(ok1207) alone diminishes dauer formation.


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

3-phosphoinositide-dependent protein kinase 1


Locus: CELE_H42K12.1


Wormbase description: pdk-1 encodes the C. elegans 3-phosphoinositide-dependent kinase 1 ortholog; PDK-1 is a component of the DAF-2/insulin receptor-like signaling pathway and accordingly, functions to regulate such processes as dauer larvae formation, longevity, and salt chemotaxis learning; genetic analyses indicate that, in regulating dauer arrest, PDK-1 acts downstream of AGE-1/PI3K and upstream of the AKT-1 and AKT-2 kinases; a PDK-1::GFP fusion protein is expressed broadly beginning in late stage embryos and continuing on through adulthood; expression is seen in head, tail, and ventral cord motor neurons, pharyngeal tissues, hypodermal cells, the intestine, and the somatic gonad; in neurons, the PDK-1::GFP localizes to cell bodies and processes, with occasional expression seen in some neuronal nuclei.


Orthologs of oga-1;pdk-1 in SynergyAge
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Orthologs of oga-1 in SynergyAge
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Species Gene
Orthologs of pdk-1 in SynergyAge
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Species Gene
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Contact
Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania
Email:

Group webpage: www.aging-research.group