mes-1;vps-34

There is no network for this step.

Fullscreen mode

Hide graph

Legend

Genetic mutants with mes-1, vps-34 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Diet
OP50; HT115E
Lifespan (days)
17.1
Lifespan change (compared to wild type)
3.64%
Phenotype
RNAi inhibition of vps-34 significantly reduced the mean lifespan of germline-deficient mutant, mes-1(bn7).
Lifespan comparisons
Double mutant mes-1(bn17);vps-34(RNAi) has a lifespan of 17.1 days, while single mutant vps-34(RNAi) has a lifespan of 16.9 days, single mutant mes-1(bn17) has a lifespan of 24.8 days and wild type has a lifespan of 16.5 days.
Type of interaction
See methods
Dependent
Citation
View abstract
Lapierre LR et al., 2011, Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans. Curr Biol. 21(18):1507-14 21906946 Click here to select all mutants from this PubMed ID in the graph
Abstract
The cellular recycling process of autophagy is emerging as a key player in several longevity pathways in Caenorhabditis elegans. Here, we identify a role for autophagy in long-lived animals lacking a germline and show that autophagy and lipid metabolism work interdependently to modulate aging in this longevity model.

Search genes: mes-1 vps-34

Entrez ID
Symbol
GenAge
Wormbase ID

181362
mes-1
View on GenAge (mes-1)
WBGene00003219

Protein mes-1

Locus: CELE_F54F7.5

Wormbase description: The mes-1 gene encodes a receptor tyrosine kinase-like protein that is required for unequal cell divisions in the early embryonic germline; during embryonic cell divisions, mes-1 is involved in positioning of the early mitotic spindle and of associated P granules.

Entrez ID
Symbol
GenAge
Wormbase ID

172280
vps-34
View on GenAge (vps-34)
WBGene00006932

Phosphatidylinositol 3-kinase catalytic subunit type 3

Locus: CELE_B0025.1

Wormbase description: vps-34 encodes an ortholog of the phosphoinositide 3-kinase VPS34 in S. cerevisiae, a protein that regulates multiple steps in endocytosis, and that is required for growth at normal rates during development; in C. elegans, vps-34 is required for vesicular trafficking, including endocytosis, apoptotic cell clearance, and autophagy.

Orthologs of mes-1;vps-34 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene

Orthologs of mes-1 in SynergyAge

Show in SynergyAge
Species	Gene

Orthologs of vps-34 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	Pi3K59F
Mus musculus	Pik3c3

About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.