nhr-105;tpk-1

Lifespan changes: From wild type to nhr-105;tpk-1

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Genetic mutants with nhr-105, tpk-1 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Diet

    NGM

  • Lifespan (days)

    27.94

  • Lifespan comparisons

    Double mutant nhr-105(RNAi);tpk-1(qm162) has a lifespan of 27.94 days, while single mutant tpk-1(qm162) has a lifespan of 32.15 days.

  • Citation
    View abstract

    Khan MH et al., 2013, TAF-4 is required for the life extension of isp-1, clk-1 and tpk-1 Mit mutants. Aging (Albany NY). 5(10):741-58 PubMed 24107417 Click here to select all mutants from this PubMed ID in the graph

Search genes: nhr-105 tpk-1
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Nuclear Hormone Receptor family


Locus: CELE_C06G3.1


Wormbase description: nhr-105 encodes a nuclear receptor that is most highly conserved amongst nematode species; nhr-105 mRNA levels are upregulated in response to progesterone treatment.


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Thiamin pyrophosphokinase 1


Locus: CELE_ZK637.9


Wormbase description: none available


Orthologs of nhr-105;tpk-1 in SynergyAge
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Species Gene
Orthologs of nhr-105 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of tpk-1 in SynergyAge
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Species Gene
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Contact
Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania
Email:

Group webpage: www.aging-research.group