daf-16;tax-4

Lifespan changes: From wild type to daf-16;tax-4

There is no network for this step.
Fullscreen mode
Hide graph
Legend

Genetic mutants with daf-16, tax-4 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Lifespan (days)

    17.3

  • Lifespan change (compared to wild type)

    -7.98%

  • Phenotype

    Loss of daf-16 markedly reduced but, in most cases, did not completely eliminate lifespan extension. Thus, most of this lifespan extension requires daf-16 activity, but a fraction is daf-16 independent. daf-16 could act downstream of a sensory signal to regulate lifespan, or it could act in a parallel pathway to provide an activity that these animals simply require for their longevity.

  • Lifespan comparisons

    Double mutant daf-16(mu86);tax-4(p678) has a lifespan of 17.3 days, while single mutant tax-4(p678) has a lifespan of 36.6 days and wild type has a lifespan of 18.8 days.

  • Type of interaction
    See methods

    Contains dependence

  • Citation
    View abstract

    Apfeld J, Kenyon C, 1999, Regulation of lifespan by sensory perception in Caenorhabditis elegans. Nature. 402(6763):804-9 PubMed 10617200 Click here to select all mutants from this PubMed ID in the graph

Search genes: daf-16 tax-4
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Forkhead box protein O;hypothetical protein

Locus: CELE_R13H8.1

Wormbase description: daf-16 encodes the sole C. elegans forkhead box O (FOXO) homologue; DAF-16 functions as a transcription factor that acts in the insulin/IGF-1-mediated signaling (IIS) pathway that regulates dauer formation, longevity, fat metabolism, stress response, and innate immunity; DAF-16 regulates these various processes through isoform-specific expression, isoform-specific regulation by different AKT kinases, and differential regulation of target genes; DAF-16 can interact with the CBP-1 transcription cofactor in vitro, and interacts genetically with other genes in the insulin signaling and with daf-12, which encodes a nuclear hormone receptor; DAF-16 is activated in response to DNA damage during development and co-regulated by EGL-27, alleviates DNA-damage-induced developmental arrest by inducing DAF-16-associated element (DAE)-regulated genes; DAF-16 is broadly expressed but displays isoform-specific tissue enrichment; DAF-16 localizes to both the cytoplasm and the nucleus, with the ratio between the two an important regulator of function.

  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Cyclic nucleotide-gated cation channel

Locus: CELE_ZC84.2

Wormbase description: tax-4 encodes a a cyclic nucleotide-gated channel subunit orthologous to the human gene ROD PHOTORECEPTOR CGMP-GATED CHANNEL (CNGA1; OMIM:123825); tax-4 is required for chemosensation and thermosensation; a TAX-4::GFP fusion protein is expressed in sensory neurons where it localizes to the cilia.

Orthologs of daf-16;tax-4 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of daf-16 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of tax-4 in SynergyAge
Show in SynergyAge
Species Gene
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Contact
Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania
Email:

Group webpage: www.aging-research.group