Nf1;rut

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Genetic mutants with Nf1, rut alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Strain
rut[1];NF1[P2]
Temperature °C
25
Diet
cornmeal agar medium
Lifespan (days)
19.0
Lifespan change (compared to wild type)
-56.82%
Phenotype
Two rutabaga mutants (rut 1), had significantly shortened life spans, and the rut and NF1 double mutant (rut;NF1 P2 ) did not further shorten the life span, implicating cAMP in mediating longevity.
Lifespan comparisons
Double mutant Nf1(DF);rut(DF) has a lifespan of 19.0 days, while single mutant rut(DF) has a lifespan of 33.0 days, single mutant Nf1(DF) has a lifespan of 34.0 days and wild type has a lifespan of 44.0 days.
Type of interaction
See methods
Synergistic (negative)
Citation
View abstract
Tong JJ et al., 2007, Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogaster. Nat Genet. 39(4):476-85 17369827 Click here to select all mutants from this PubMed ID in the graph
Abstract
We investigated the pathophysiology of neurofibromatosis-1 (NF1) in Drosophila melanogaster by inactivation or overexpression of the NF1 gene. NF1 gene mutants had shortened life spans and increased vulnerability to heat and oxidative stress in association with reduced mitochondrial respiration and elevated reactive oxygen species (ROS) production. Flies overexpressing NF1 had increased life spans, improved reproductive fitness, increased resistance to oxidative and heat stress in association with increased mitochondrial respiration and a 60% reduction in ROS production. These phenotypic effects proved to be modulated by the adenylyl cyclase/cyclic AMP (cAMP)/protein kinase A pathway, not the Ras/Raf pathway. Treatment of wild-type D. melanogaster with cAMP analogs increased their life span, and treatment of NF1 mutants with metalloporphyrin catalytic antioxidant compounds restored their life span. Thus, neurofibromin regulates longevity and stress resistance through cAMP regulation of mitochondrial respiration and ROS production, and NF1 may be treatable using catalytic antioxidants.

Strain
rut[1];NF1[P2]
Temperature °C
25
Diet
cornmeal agar medium
Lifespan (days)
25.0
Lifespan change (compared to wild type)
-50.00%
Phenotype
Two rutabaga mutants (rut 1), had significantly shortened life spans, and the rut and NF1 double mutant (rut;NF1 P2 ) did not further shorten the life span, implicating cAMP in mediating longevity.
Lifespan comparisons
Double mutant Nf1(DF);rut(DF) has a lifespan of 25.0 days, while single mutant rut(DF) has a lifespan of 20.0 days, single mutant Nf1(DF) has a lifespan of 38.0 days and wild type has a lifespan of 50.0 days.
Type of interaction
See methods
Dependent
Citation
View abstract
Tong JJ et al., 2007, Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogaster. Nat Genet. 39(4):476-85 17369827 Click here to select all mutants from this PubMed ID in the graph
Abstract
We investigated the pathophysiology of neurofibromatosis-1 (NF1) in Drosophila melanogaster by inactivation or overexpression of the NF1 gene. NF1 gene mutants had shortened life spans and increased vulnerability to heat and oxidative stress in association with reduced mitochondrial respiration and elevated reactive oxygen species (ROS) production. Flies overexpressing NF1 had increased life spans, improved reproductive fitness, increased resistance to oxidative and heat stress in association with increased mitochondrial respiration and a 60% reduction in ROS production. These phenotypic effects proved to be modulated by the adenylyl cyclase/cyclic AMP (cAMP)/protein kinase A pathway, not the Ras/Raf pathway. Treatment of wild-type D. melanogaster with cAMP analogs increased their life span, and treatment of NF1 mutants with metalloporphyrin catalytic antioxidant compounds restored their life span. Thus, neurofibromin regulates longevity and stress resistance through cAMP regulation of mitochondrial respiration and ROS production, and NF1 may be treatable using catalytic antioxidants.

Search genes: Nf1 rut

Entrez ID
Symbol
GenAge
FlyBase ID

43149
Nf1
View on GenAge (Nf1)
FBgn0015269

Neurofibromin 1

Locus: Dmel_CG8318

Entrez ID
Symbol
GenAge
FlyBase ID

32406
rut
View on GenAge (rut)
FBgn0003301

rutabaga

Locus: Dmel_CG9533

Orthologs of Nf1;rut in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Mus musculus	Adcy1;Nf1
Mus musculus	Nf1;Adcy1

Orthologs of Nf1 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Mus musculus	Nf1

Orthologs of rut in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Caenorhabditis elegans	acy-4
Mus musculus	Adcy1