Lip2;rpr

Lifespan changes: From wild type to Lip2;rpr DF = decrease in function; IF = increase in function

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Genetic mutants with Lip2, rpr alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Strain

    rpr[UAS.C];dil[2]

  • Lifespan (days)

    64.0

  • Lifespan change (compared to wild type)

    36.17%

  • Phenotype

    mNSC-ablated flies are long-lived and females show reduced fecundity.

  • Lifespan comparisons

    Double mutant Lip2(DF);rpr(DF) has a lifespan of 64.0 days, while single mutant rpr(DF) has a lifespan of 54.0 days, single mutant Lip2(DF) has a lifespan of 47.0 days and wild type has a lifespan of 47.0 days.

  • Type of interaction
    See methods

    Synergistic (positive)

  • Citation
    View abstract

    Broughton SJ et al., 2005, Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands. Proc Natl Acad Sci U S A. 102(8):3105-10 PubMed 15708981 Click here to select all mutants from this PubMed ID in the graph

  • Strain

    rpr[UAS.C];dil[2]

  • Lifespan (days)

    56.0

  • Lifespan change (compared to wild type)

    60.00%

  • Phenotype

    mNSC-ablated flies are long-lived and females show reduced fecundity.

  • Lifespan comparisons

    Double mutant Lip2(DF);rpr(DF) has a lifespan of 56.0 days, while single mutant rpr(DF) has a lifespan of 42.0 days, single mutant Lip2(DF) has a lifespan of 32.0 days and wild type has a lifespan of 35.0 days.

  • Type of interaction
    See methods

    Enhancer, opposite lifespan effects

  • Citation
    View abstract

    Broughton SJ et al., 2005, Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands. Proc Natl Acad Sci U S A. 102(8):3105-10 PubMed 15708981 Click here to select all mutants from this PubMed ID in the graph

  • Strain

    rpr[UAS.C];dil[2]

  • Lifespan (days)

    41.0

  • Lifespan change (compared to wild type)

    20.59%

  • Phenotype

    mNSC-ablated flies are long-lived and females show reduced fecundity.

  • Lifespan comparisons

    Double mutant Lip2(DF);rpr(DF) has a lifespan of 41.0 days, while single mutant rpr(DF) has a lifespan of 35.0 days, single mutant Lip2(DF) has a lifespan of 37.0 days and wild type has a lifespan of 34.0 days.

  • Type of interaction
    See methods

    Synergistic (positive)

  • Citation
    View abstract

    Broughton SJ et al., 2005, Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands. Proc Natl Acad Sci U S A. 102(8):3105-10 PubMed 15708981 Click here to select all mutants from this PubMed ID in the graph

Search genes: Lip2 rpr
  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID

Lipase 2


Locus: Dmel_CG17116


  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID

reaper


Locus: Dmel_CG4319


Orthologs of Lip2;rpr in SynergyAge
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Species Gene
Orthologs of Lip2 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of rpr in SynergyAge
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Species Gene
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Contact
Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania
Email:

Group webpage: www.aging-research.group