nhr-170;nhr-231;rrf-3

Genetic mutants with nhr-170, nhr-231, rrf-3 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Diet

    OP50

  • Lifespan (days)

    26.5

  • Lifespan comparisons

    Triple mutant nhr-170(RNAi);nhr-231(RNAi);rrf-3(pk1426) has a lifespan of 26.5 days, while single mutant rrf-3(pk1426) has a lifespan of 17.8 days.

  • Citation
    View abstract

    Ewald CY et al., 2015, Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity. Nature. 519(7541):97-101 PubMed 25517099 Click here to select all mutants from this PubMed ID in the graph

Search genes: nhr-170 nhr-231 rrf-3 nhr-170;nhr-231;rrf-3
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Nuclear Hormone Receptor family


Locus: CELE_C54E10.5


Wormbase description: none available


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Nuclear Hormone Receptor family


Locus: CELE_Y17D7B.1


Wormbase description: none available


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

RNA-dependent RNA polymerase Family


Locus: CELE_F10B5.7


Wormbase description: rrf-3 encodes an RNA-directed RNA polymerase (RdRP) homolog that inhibits somatic RNAi, and thus promotes activity of repeated genes (e.g., multicopy transgenic arrays); the effect of RRF-3 on RNAi is opposite to that of RRF-1 (which stimulates somatic RNAi), which might arise from competition by RRF-3 with RRF-1 or EGO-1 in RNAi formation; rrf-3(allele) or rrf-3(allele2) mutants are hypersensitive to somatic RNAi, and conversely suppress the activity of an integrated rol6 (su1006) transgene.


Orthologs of nhr-170;nhr-231;rrf-3 in SynergyAge
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Orthologs of nhr-170 in SynergyAge
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Orthologs of nhr-231 in SynergyAge
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Orthologs of rrf-3 in SynergyAge
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About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Contact
Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania
Email:

Group webpage: www.aging-research.group