daf-16;tcer-1

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Genetic mutants with daf-16, tcer-1 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Lifespan (days)
17.7
Lifespan change (compared to wild type)
-3.80%
Phenotype
The lifespan extension obtained by tcer-1 overexpression required the presence of wild-type daf-16
Lifespan comparisons
Double mutant daf-16(mu86);tcer-1(OE) has a lifespan of 17.7 days, while single mutant tcer-1(OE) has a lifespan of 21.1 days and wild type has a lifespan of 18.4 days.
Type of interaction
See methods
Contains dependence
Citation
View abstract
Ghazi A et al., 2009, A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans. PLoS Genet. 5(9):e1000639 19749979 Click here to select all mutants from this PubMed ID in the graph
Abstract
In Caenorhabditis elegans and Drosophila melanogaster, the aging of the soma is influenced by the germline. When germline-stem cells are removed, aging slows and lifespan is increased. The mechanism by which somatic tissues respond to loss of the germline is not well-understood. Surprisingly, we have found that a predicted transcription elongation factor, TCER-1, plays a key role in this process. TCER-1 is required for loss of the germ cells to increase C. elegans' lifespan, and it acts as a regulatory switch in the pathway. When the germ cells are removed, the levels of TCER-1 rise in somatic tissues. This increase is sufficient to trigger key downstream events, as overexpression of tcer-1 extends the lifespan of normal animals that have an intact reproductive system. Our findings suggest that TCER-1 extends lifespan by promoting the expression of a set of genes regulated by the conserved, life-extending transcription factor DAF-16/FOXO. Interestingly, TCER-1 is not required for DAF-16/FOXO to extend lifespan in animals with reduced insulin/IGF-1 signaling. Thus, TCER-1 specifically links the activity of a broadly deployed transcription factor, DAF-16/FOXO, to longevity signals from reproductive tissues.

Temperature °C
20
Lifespan (days)
17.6
Lifespan change (compared to wild type)
-16.59%
Phenotype
The lifespan extension obtained by tcer-1 overexpression required the presence of wild-type daf-16
Lifespan comparisons
Double mutant daf-16(mu86);tcer-1(OE) has a lifespan of 17.6 days, while single mutant tcer-1(OE) has a lifespan of 22.4 days and wild type has a lifespan of 21.1 days.
Type of interaction
See methods
Contains dependence
Citation
View abstract
Ghazi A et al., 2009, A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans. PLoS Genet. 5(9):e1000639 19749979 Click here to select all mutants from this PubMed ID in the graph
Abstract
In Caenorhabditis elegans and Drosophila melanogaster, the aging of the soma is influenced by the germline. When germline-stem cells are removed, aging slows and lifespan is increased. The mechanism by which somatic tissues respond to loss of the germline is not well-understood. Surprisingly, we have found that a predicted transcription elongation factor, TCER-1, plays a key role in this process. TCER-1 is required for loss of the germ cells to increase C. elegans' lifespan, and it acts as a regulatory switch in the pathway. When the germ cells are removed, the levels of TCER-1 rise in somatic tissues. This increase is sufficient to trigger key downstream events, as overexpression of tcer-1 extends the lifespan of normal animals that have an intact reproductive system. Our findings suggest that TCER-1 extends lifespan by promoting the expression of a set of genes regulated by the conserved, life-extending transcription factor DAF-16/FOXO. Interestingly, TCER-1 is not required for DAF-16/FOXO to extend lifespan in animals with reduced insulin/IGF-1 signaling. Thus, TCER-1 specifically links the activity of a broadly deployed transcription factor, DAF-16/FOXO, to longevity signals from reproductive tissues.

Temperature °C
20
Lifespan (days)
16.9
Lifespan change (compared to wild type)
2.42%
Phenotype
The lifespan extension obtained by tcer-1 overexpression required the presence of wild-type daf-16
Lifespan comparisons
Double mutant daf-16(mu86);tcer-1(OE) has a lifespan of 16.9 days, while single mutant tcer-1(OE) has a lifespan of 20.5 days and wild type has a lifespan of 16.5 days.
Type of interaction
See methods
Contains dependence
Citation
View abstract
Ghazi A et al., 2009, A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans. PLoS Genet. 5(9):e1000639 19749979 Click here to select all mutants from this PubMed ID in the graph
Abstract
In Caenorhabditis elegans and Drosophila melanogaster, the aging of the soma is influenced by the germline. When germline-stem cells are removed, aging slows and lifespan is increased. The mechanism by which somatic tissues respond to loss of the germline is not well-understood. Surprisingly, we have found that a predicted transcription elongation factor, TCER-1, plays a key role in this process. TCER-1 is required for loss of the germ cells to increase C. elegans' lifespan, and it acts as a regulatory switch in the pathway. When the germ cells are removed, the levels of TCER-1 rise in somatic tissues. This increase is sufficient to trigger key downstream events, as overexpression of tcer-1 extends the lifespan of normal animals that have an intact reproductive system. Our findings suggest that TCER-1 extends lifespan by promoting the expression of a set of genes regulated by the conserved, life-extending transcription factor DAF-16/FOXO. Interestingly, TCER-1 is not required for DAF-16/FOXO to extend lifespan in animals with reduced insulin/IGF-1 signaling. Thus, TCER-1 specifically links the activity of a broadly deployed transcription factor, DAF-16/FOXO, to longevity signals from reproductive tissues.

Temperature °C
20
Lifespan (days)
16.1
Lifespan change (compared to wild type)
-2.42%
Phenotype
The lifespan extension obtained by tcer-1 overexpression required the presence of wild-type daf-16
Lifespan comparisons
Double mutant daf-16(mu86);tcer-1(OE) has a lifespan of 16.1 days, while single mutant tcer-1(OE) has a lifespan of 20.5 days and wild type has a lifespan of 16.5 days.
Type of interaction
See methods
Contains dependence
Citation
View abstract
Ghazi A et al., 2009, A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans. PLoS Genet. 5(9):e1000639 19749979 Click here to select all mutants from this PubMed ID in the graph
Abstract
In Caenorhabditis elegans and Drosophila melanogaster, the aging of the soma is influenced by the germline. When germline-stem cells are removed, aging slows and lifespan is increased. The mechanism by which somatic tissues respond to loss of the germline is not well-understood. Surprisingly, we have found that a predicted transcription elongation factor, TCER-1, plays a key role in this process. TCER-1 is required for loss of the germ cells to increase C. elegans' lifespan, and it acts as a regulatory switch in the pathway. When the germ cells are removed, the levels of TCER-1 rise in somatic tissues. This increase is sufficient to trigger key downstream events, as overexpression of tcer-1 extends the lifespan of normal animals that have an intact reproductive system. Our findings suggest that TCER-1 extends lifespan by promoting the expression of a set of genes regulated by the conserved, life-extending transcription factor DAF-16/FOXO. Interestingly, TCER-1 is not required for DAF-16/FOXO to extend lifespan in animals with reduced insulin/IGF-1 signaling. Thus, TCER-1 specifically links the activity of a broadly deployed transcription factor, DAF-16/FOXO, to longevity signals from reproductive tissues.

Temperature °C
20
Lifespan (days)
16.6
Lifespan change (compared to wild type)
-21.33%
Phenotype
The lifespan extension obtained by tcer-1 overexpression required the presence of wild-type daf-16
Lifespan comparisons
Double mutant daf-16(mu86);tcer-1(OE) has a lifespan of 16.6 days, while single mutant tcer-1(OE) has a lifespan of 22.4 days and wild type has a lifespan of 21.1 days.
Type of interaction
See methods
Contains dependence
Citation
View abstract
Ghazi A et al., 2009, A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans. PLoS Genet. 5(9):e1000639 19749979 Click here to select all mutants from this PubMed ID in the graph
Abstract
In Caenorhabditis elegans and Drosophila melanogaster, the aging of the soma is influenced by the germline. When germline-stem cells are removed, aging slows and lifespan is increased. The mechanism by which somatic tissues respond to loss of the germline is not well-understood. Surprisingly, we have found that a predicted transcription elongation factor, TCER-1, plays a key role in this process. TCER-1 is required for loss of the germ cells to increase C. elegans' lifespan, and it acts as a regulatory switch in the pathway. When the germ cells are removed, the levels of TCER-1 rise in somatic tissues. This increase is sufficient to trigger key downstream events, as overexpression of tcer-1 extends the lifespan of normal animals that have an intact reproductive system. Our findings suggest that TCER-1 extends lifespan by promoting the expression of a set of genes regulated by the conserved, life-extending transcription factor DAF-16/FOXO. Interestingly, TCER-1 is not required for DAF-16/FOXO to extend lifespan in animals with reduced insulin/IGF-1 signaling. Thus, TCER-1 specifically links the activity of a broadly deployed transcription factor, DAF-16/FOXO, to longevity signals from reproductive tissues.

Search genes: daf-16 tcer-1

Entrez ID
Symbol
GenAge
Wormbase ID

172981
daf-16
View on GenAge (daf-16)
WBGene00000912

Forkhead box protein O;hypothetical protein

Locus: CELE_R13H8.1

Wormbase description: daf-16 encodes the sole C. elegans forkhead box O (FOXO) homologue; DAF-16 functions as a transcription factor that acts in the insulin/IGF-1-mediated signaling (IIS) pathway that regulates dauer formation, longevity, fat metabolism, stress response, and innate immunity; DAF-16 regulates these various processes through isoform-specific expression, isoform-specific regulation by different AKT kinases, and differential regulation of target genes; DAF-16 can interact with the CBP-1 transcription cofactor in vitro, and interacts genetically with other genes in the insulin signaling and with daf-12, which encodes a nuclear hormone receptor; DAF-16 is activated in response to DNA damage during development and co-regulated by EGL-27, alleviates DNA-damage-induced developmental arrest by inducing DAF-16-associated element (DAE)-regulated genes; DAF-16 is broadly expressed but displays isoform-specific tissue enrichment; DAF-16 localizes to both the cytoplasm and the nucleus, with the ratio between the two an important regulator of function.

Entrez ID
Symbol
GenAge
Wormbase ID

174150
tcer-1
View on GenAge (tcer-1)
WBGene00022855

TransCription Elongation Regulator homolog

Locus: CELE_ZK1127.9

Wormbase description: none available

Orthologs of daf-16;tcer-1 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Mus musculus	Foxo6;Tcerg1
Mus musculus	Foxo1;Tcerg1
Mus musculus	Foxo4;Tcerg1
Mus musculus	Foxo3;Tcerg1
Mus musculus	Tcerg1;Foxo6
Mus musculus	Tcerg1;Foxo1
Mus musculus	Tcerg1;Foxo4
Mus musculus	Tcerg1;Foxo3

Orthologs of daf-16 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Mus musculus	Foxo6
Mus musculus	Foxo1
Mus musculus	Foxo4
Mus musculus	Foxo3

Orthologs of tcer-1 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Mus musculus	Tcerg1