sod-1;sod-5

Lifespan changes: From wild type to sod-1;sod-5 / From sod-1;sod-5 to multiple mutants

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Genetic mutants with sod-1, sod-5 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Lifespan (days)

    18.2

  • Lifespan change (compared to wild type)

    2.82%

  • Phenotype

    Examining the lifespan of sod-1 double deletion mutants revealed that deletion of sod-5 did not shorten the lifespan of sod-1 mutant worms

  • Lifespan comparisons

    Double mutant sod-1(tm783);sod-5(tm1246) has a lifespan of 18.2 days, while single mutant sod-1(tm783) has a lifespan of 17.3 days, single mutant sod-5(tm1246) has a lifespan of 16.4 days and wild type has a lifespan of 17.7 days.

  • Type of interaction
    See methods

    Antagonistic (positive)

  • Citation
    View abstract

    Van Raamsdonk JM, Hekimi S, 2009, Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans. PLoS Genet. 5(2):e1000361 PubMed 19197346 Click here to select all mutants from this PubMed ID in the graph

Search genes: sod-1 sod-5
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Superoxide dismutase [Cu-Zn]


Locus: CELE_C15F1.7


Wormbase description: sod-1 encodes the copper/zinc superoxide dismustase, an enzyme that is known to protect cells from oxidative damage; superoxide dismutase activity can be detected in worm extracts; sod-1 activity has been implicated in the increased life-span of dauer larvae where this enzyme demonstrates the highest activity compared to other life-stages as well as in the increased life span of age-1 mutants and their resistance to oxidative damage; sod-1 modulates the effect of let-60 ras on vulval and germline development via cytoplasmic reactive oxygen species; unlike other eukaryotic superoxide dismutases, sod-1 does not require the copper chaperone CCS for its activity and instead uses a glutathione pathway for acquiring copper; in humans, mutation of SOD1 (OMIM:147450) leads to amyotrophic lateral sclerosis (OMIM:105400).


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Superoxide dismutase [Cu-Zn]


Locus: CELE_ZK430.3


Wormbase description: sod-5 encodes one of five superoxide (SOD) isozymes in C. elegans; along with SOD-1, SOD-5 is predicted to be one of two cytoplasmic Cu/Zn SODs in C. elegans; sod-5 expression is increased in sod-1 mutant animals and likewise, sod-1 expression is increased in sod-5 mutants, suggesting a possible mechanism of functional compensation between these two genes; the sod-5 promoter contains one copy of a DAF-16 binding element, consistent with observations that sod-5 mRNA levels increase in insulin/IGF-1 signaling pathway mutants.


Orthologs of sod-1;sod-5 in SynergyAge
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Species Gene
Drosophila melanogaster Sod1;Sod1
Orthologs of sod-1 in SynergyAge
Show in SynergyAge
Species Gene
Drosophila melanogaster Sod1
Mus musculus Sod1
Orthologs of sod-5 in SynergyAge
Show in SynergyAge
Species Gene
Drosophila melanogaster Sod1
Mus musculus Sod1
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Contact
Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania
Email:

Group webpage: www.aging-research.group